They will be joined by newly-crowned PGA Championship winner Xander Schauffele, meaning the top three players in the world will be grouped together in North Carolina.
The heavyweight trio will tee off from the first at 1:14pm ET on Thursday and on the 10th at 7:29am on Friday.
Elsewhere, Tiger Woods will play his first two rounds with Matthew Fitzpatrick and Will Zalatoris.
They will start on the 10th at 7:29am on Thursday and from the first at 1:14pm on Friday.
There are a number of eye-catching groups elsewhere among the field, too.
Justin Thomas, Collin Morikawa and Brooks Koepka are all major champions and will be hoping to add another this week.
Another trio of major champions – Hideki Matsuyama, Jon Rahm and Jordan Spieth – will tee it up together as well.
There will also be plenty of intrigue around the group featuring Tony Finau, Ludvig Aberg and Dustin Johnson.
Fresh off of his win at the Memorial Tournament last week, Scheffler is the favorite to win another major title this week.
The 27-year-old has already raked in a recorded $24million in earnings this season and is riding a streak of 11 consecutive top 10 finishes. Despite taking a few weeks off following the berth of his first child last month, Scheffler has remained in dominant form.
‘It it’s a good place to be,’ Scheffler said after holding on to win the Memorial by a shot on Sunday. ‘I like how my game’s feeling right now. I feel like I’ve been playing some good golf. It’s great to see some results too and some wins.
‘Out here the margins are so small between winning and losing. It’s a putt or a shot here or there. Fortunately, today I was able to hit the shots when I needed to and hopefully going into next week I’m going it stick to my game plan and prepare the way I usually would and get ready to go out and compete again on Thursday.’
Scheffler said he doesn’t feel as though he has a target on his back, however.
‘Just because I’m the favorite (at Pinehurst) doesn’t really have any affect on my score,’ he said. ‘I think we all start at even par, if I remember correctly.’
FULL US OPEN ROUND ONE AND TWO TEE TIMES
Thursday (June 13), Hole #1 / Friday (June 14), Hole #10
6:45 a.m. / 12:30 p.m. – Michael McGowan, Carter Jenkins, Logan McAllister
6:56 a.m. / 12:41 p.m. – Frederik Kjettrup, Christopher Petefish, Parker Bell
7:07 a.m. / 12:52 p.m. – Omar Morales, Max Greyserman, Casey Jarvis
7:18 a.m. / 1:03 p.m. – Corey Conners, Stephan Jaeger, Emiliano Grillo,
7:29 a.m. / 1:14 p.m. – Ryo Ishikawa, Francesco Molinari, Sergio Garcia
7:40 a.m. / 1:25 p.m. – Justin Thomas, Collin Morikawa, Brooks Koepka
7:51 a.m. / 1:36 p.m. – Rickie Fowler, Adam Hadwin, Phil Mickelson
8:02 a.m. / 1:47 p.m. – Min Woo Lee, Sahith Theegala, Nicolai Højgaard
8:13 a.m. / 1:58 p.m. – Si Woo Kim, Matthieu Pavon, Sungjae Im
8:24 a.m. / 2:09 p.m. – Nico Echavarria, Robert Rock, Neal Shipley
8:35 a.m. / 2:20 p.m. – Takumi Kanaya, Stewart Hagestad, Mac Meissner
8:46 a.m. / 2:31 p.m. – Isaiah Salinda, Bryan Kim, Jim Herman
8:57 a.m. / 2:42 p.m. – Carson Schaake, Charles Reiter, Colin Prater
Thursday (June 13), Hole #1/ Friday (June 14), Hole #10
12:30 p.m. / 6:45 a.m. – Jason Scrivener, Brandon Robinson Thompson, Brendan Valdes
12:41 p.m. / 6:56 a.m. – Santiago de la Fuente, Sam Bairstow, Eugenio Chacarra
12:52 p.m. / 7:07 a.m. – Kurt Kitayama, Chico, Taylor Moore, Christiaan Bezuidenhout
1:03 p.m. / 7:18 a.m. – Jason Day, Harris English, Tom Kim
1:14 p.m. / 7:29 a.m. – Rory McIlroy, Xander Schauffele, Scottie Scheffler
1:25 p.m. / 7:40 a.m. – Brian Harman, Nick Dunlap, Wyndham Clark
1:36 p.m. / 7:51 a.m. – Hideki Matsuyama, Jon Rahm, Jordan Spieth
1:47 p.m. / 8:02 a.m. – Shane Lowry, Keegan Bradley, Martin Kaymer
1:58 p.m. / 8:13 a.m. – Akshay Bhatia, Eric Cole, Erik van Rooyen
2:09 p.m. / 8:24 a.m. – Brendon Todd, Taylor Pendrith, Alex Noren
2:20 p.m. / 8:35 a.m. – Thomas Detry, Brian Campbell, Jackson Buchanan
2:31 p.m. / 8:46 a.m. – Taisei Shimizu, Gunnar Broin, Maxwell Moldovan
2:42 p.m. / 8:57 a.m. – Sung Kang, Riki Kawamoto, John Chin
Thursday (June 13), Hole #10/ Friday (June 14), Hole #1
6:45 a.m. / 12:30 p.m. – Rico Hoey, Tom McKibbin, Matteo Manassero
6:56 a.m. / 12:41 p.m. – Dean Burmester, Rikuya Hoshino, Seamus Power
7:07 a.m. / 12:52 p.m. – S.H. Kim, Justin Lower, Tim Widing
7:18 a.m. / 1:03 p.m. – Lucas Glover, Sam Burns, Cameron Smith
7:29 a.m. / 1:14 p.m. – Will Zalatoris, Matt Fitzpatrick, Tiger Woods
7:40 a.m. / 1:25 p.m. – Patrick Cantlay, Matt Kuchar, Russell Henley
7:51 a.m. / 1:36 p.m. – Tony Finau, Ludvig Aberg, Dustin Johnson
8:02 a.m. / 1:47 p.m. – Justin Rose, Gary Woodland, Webb Simpson
8:13 a.m. / 1:58 p.m. – Daniel Berger, Ryan Fox, David Puig
8:24 a.m. / 2:09 p.m. – Byeong Hun An, Sam Bennett, Edoardo Molinari
8:35 a.m. / 2:20 p.m. – Austin Eckroat, Adrian Meronk, Cam Davis
8:46 a.m. / 2:31 p.m. – Aaron Rai, Davis Thompson, Zac Blair
8:57 a.m. / 2:42 p.m. – Willie Mack III, Richard Mansell, Ashton McCulloch
Thursday (June 13), Hole #10/ Friday (June 14), Hole #1
12:30 p.m. / 6:45 a.m. – Greyson Sigg, Grant Forrest, Wells Williams
12:41 p.m. / 6:56 a.m. – Chesson Hadley, Mark Hubbard, Adam Svensson
12:52 p.m. / 7:07 a.m. – Beau Hossler, Victor Perez, Adam Schenk
1:03 p.m. / 7:18 a.m. – Robert MacIntyre, Nick Taylor, Mackenzie Hughes
1:14 p.m. / 7:29 a.m. – Tyrrell Hatton, Tommy Fleetwood, Tom Hoge
1:25 p.m. / 7:40 a.m. – Bryson DeChambeau, Viktor Hovland, Max Homa
1:36 p.m. / 7:51 a.m. – Sepp Straka, Peter Malnati, J.T. Poston
1:47 p.m. / 8:02 a.m. – Gordon Sargent, Jake Knapp, Cameron Young
1:58 p.m. / 8:13 a.m. – Chris Kirk, Billy Horschel, Adam Scott
2:09 p.m. / 8:24 a.m. – Ben Kohles, Denny McCarthy, Ben James
2:20 p.m. / 8:35 a.m. – Frankie Capan III, Andy Svoboda, Luke Clanton
2:31 p.m. / 8:46 a.m. – Harry Higgs, Hiroshi Tai, Brandon Wu
2:42 p.m. / 8:57 a.m. – Joey Vrzich, Chris Naegel, Otto Black
All Times EDT