The show, which matches two people who marry upon their first meeting, is now recruiting participants from across the UK.
The series has seen four couples starting families after being matched on the show.
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The last series, aired in autumn 2023, was E4’s most-watched and the second most-streamed programme in the UK.
Following their wedding, the couples enjoy a luxury honeymoon before moving in together with other couples in the experiment.
They face weekly challenges designed to strengthen their relationship, attend dinner parties, participate in a weekly commitment ceremony, where they discuss their relationships with the experts, and ultimately then decide if they want to stay in the experiment or go their separate ways.
Applications for the new series can be made via the show’s official website at shortaudition.com/MAFSUK5.