A freight train has derailed in Cumbria causing major delays on the rail network.
The train derailed between Penrith North Lakes and Oxenholme Lake District just before 17:00 BST, blocking the line.
Avanti West Coast services between Preston and Glasgow/Edinburgh have been cancelled for the remainder of Wednesday.
It has advised passengers not to travel north of Preston.
TransPennine Express services between Manchester Airport and Carlisle/Edinburgh and between Liverpool Lime Street/Preston and Glasgow Central have also been affected.
TransPennine said response staff are being sent to the scene.
Avanti said customers with tickets dated for Wednesday can use them at any time on Thursday on the same route.
Avanti said LNER and TransPennine Express were accepting affected passengers via any reasonable route.
National Rail said replacement bus services have “been requested”.