In Molina de Segura, also in the Murcia region, rescue services saved four people from stranded cars, including a woman and her eight-year-old daughter.
The heavy rain also caused flash floods in the neighbouring provinces of Alicante and Albacete.
In total, emergency services responded to 589 calls for help, including 40 cases where people had to be rescued from floodwaters.
Majorca, off Spain’s east coast, has also been hit by heavy rainfall this week. On Tuesday, Majorca airport had to suspend flights when the runway flooded.
Officials at the airport said that 100 of flights scheduled to operate on Tuesday, including many from British travel hubs such as Gatwick, Luton and Bristol, had been affected by the storms.
The storm also brought strong winds, with two trees falling in Murcia and blocking a branch of the city’s tramway.