The house was previously occupied by John Flamsteed who, the civic society said, created Greenwich Mean Time inside the building.
It was also home of clockmaker and scientist John Whitehurst.
Russell Rigby, managing director from Rigby & Co, agent for the Dewinter family, said: “The owners are not surprised Historic England have listed the building at the front of the site. It has a tremendously rich history.
“It is a building that does deserve to be celebrated and protected.”
Talking about plans announced earlier this year to develop land at the back of the building, he said they were “starting to gather some pace”.
The owners entered a joint venture with an unnamed Derby-based property company to develop this land.
Mr Rigby said subject to planning approval – and an application has not yet been put in – they were intending to build a mixture of residential accommodation, possibly geared towards student accommodation, with potentially commercial space too.
While he said landowners were also looking at different ideas to enhance and refurbish the building.
He said: “Clearly, any reuse will have to respect the newly-found listed status.
“So the fact that the building is now listed absolutely accords with the sentiment of how the building should be looked after going forward, and brought back into use.
“Developments at the back of the site will obviously provide some economic funding that can be invested in the front building.”