Ms Marquez responded: “I’m talking about women in general. We’ve got a programme for trans women as well.”
The audience member then sat down, and was allowed to stay in her seat for the rest of the event.
During her address, Meghan stunned the audience by saying a few words in Spanish.
Meghan and Prince Harry began their tour in Colombia four days ago. They have used their visit to highlight issues close to their heart.
The pair were invited to the Latin American nation by the country’s vice president after she saw their documentary on Netflix, Harry & Meghan, and heard about the duchess’s life story which she said deeply touched her.
Ms Marquez, the first black woman in the country to hold the position of vice president, opened up about the reason behind the couple’s invitation during a press conference.